ACACB and HLCS

Data Source:
BioGRID (enzymatic study)

		ACACB	HLCS
Description		acetyl-CoA carboxylase beta	holocarboxylase synthetase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Biotin Binding Identical Protein Binding Metal Ion Binding	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding
	Biological Process	Acetyl-CoA Metabolic Process Fatty Acid Biosynthetic Process Carnitine Shuttle Negative Regulation Of Gene Expression Positive Regulation Of Lipid Storage Regulation Of Glucose Metabolic Process Response To Organic Cyclic Compound Positive Regulation Of Cellular Metabolic Process Response To Nutrient Levels Negative Regulation Of Fatty Acid Beta-oxidation Response To Drug Negative Regulation Of Catalytic Activity Regulation Of Cholesterol Biosynthetic Process Protein Homotetramerization Positive Regulation Of Heart Growth Energy Homeostasis Malonyl-CoA Biosynthetic Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Protein Phosphopantetheinylation Response To Biotin Histone Biotinylation
Pathways		ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine metabolism Activation of gene expression by SREBF (SREBP)	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		Biotin Adenine Soraphen A 2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid Haloxyfop-P	Biotin
Diseases			Holocarboxylase synthetase deficiency
GWAS		Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Triglyceride levels ( 32203549) Triglycerides ( 30275531)	Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		2 interacting genes: HLCS PRKAA2	8 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 SNX27 SPATA46
Entrez ID		32	3141
HPRD ID		07044	08360
Ensembl ID		ENSG00000076555	ENSG00000159267
Uniprot IDs		O00763	P50747
PDB IDs		2DN8 2HJW 2KCC 3FF6 3GID 3GLK 3JRW 3JRX 3TDC 4HQ6 5KKN
Enriched GO Terms of Interacting Partners?
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