HLCS and ACACB

Data Source:
BioGRID (enzymatic study)

		HLCS	ACACB
Description		holocarboxylase synthetase	acetyl-CoA carboxylase beta
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding	Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Biotin Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Protein Phosphopantetheinylation Response To Biotin Histone Biotinylation	Acetyl-CoA Metabolic Process Fatty Acid Biosynthetic Process Carnitine Shuttle Negative Regulation Of Gene Expression Positive Regulation Of Lipid Storage Regulation Of Glucose Metabolic Process Response To Organic Cyclic Compound Positive Regulation Of Cellular Metabolic Process Response To Nutrient Levels Negative Regulation Of Fatty Acid Beta-oxidation Response To Drug Negative Regulation Of Catalytic Activity Regulation Of Cholesterol Biosynthetic Process Protein Homotetramerization Positive Regulation Of Heart Growth Energy Homeostasis Malonyl-CoA Biosynthetic Process
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency	ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine metabolism Activation of gene expression by SREBF (SREBP)
Drugs		Biotin	Biotin Adenine Soraphen A 2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid Haloxyfop-P
Diseases		Holocarboxylase synthetase deficiency
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)	Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		8 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 SNX27 SPATA46	2 interacting genes: HLCS PRKAA2
Entrez ID		3141	32
HPRD ID		08360	07044
Ensembl ID		ENSG00000159267	ENSG00000076555
Uniprot IDs		P50747	O00763
PDB IDs			2DN8 2HJW 2KCC 3FF6 3GID 3GLK 3JRW 3JRX 3TDC 4HQ6 5KKN
Enriched GO Terms of Interacting Partners?
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