FOXA2 and GSC

Data Source:
HPRD (in vitro)

		FOXA2	GSC
Description		forkhead box A2	goosecoid homeobox
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cell Junction	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Adult Locomotory Behavior Anatomical Structure Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Regulation Of Blood Coagulation Endocrine Pancreas Development Negative Regulation Of Glucokinase Activity Positive Regulation Of Embryonic Development Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation Negative Regulation Of Detection Of Glucose	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Gastrulation Neural Crest Cell Fate Specification Dorsal/ventral Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Wnt Signaling Pathway Forebrain Development Middle Ear Morphogenesis Muscle Organ Morphogenesis Embryonic Skeletal System Morphogenesis
Pathways		Regulation of gene expression in beta cells
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 25784220) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Body size at age 10 ( 32376654) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374 20152958) Gout ( 22179738) Hypothyroidism ( 27182965) Male-pattern baldness ( 22693459 27182965) Monobrow ( 27182965) Type 2 diabetes ( 30054458 32499647) Vitamin D levels ( 26704534)	Chin dimples ( 27182965) Male-pattern baldness ( 28196072) Nonsyndromic cleft lip with cleft palate ( 28232668) Nose size ( 27182965)
Interacting Genes		9 interacting genes: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTX2 TLE1	4 interacting genes: FOXA2 SMAD1 SMAD2 SMAD3
Entrez ID		3170	145258
HPRD ID		02618	15928
Ensembl ID		ENSG00000125798	ENSG00000133937
Uniprot IDs		B0ZTD4 Q9Y261	P56915
PDB IDs		5X07	2DMU
Enriched GO Terms of Interacting Partners?
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