GSC and FOXA2

Data Source:
HPRD (in vitro)

		GSC	FOXA2
Description		goosecoid homeobox	forkhead box A2
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GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Gastrulation Neural Crest Cell Fate Specification Dorsal/ventral Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Wnt Signaling Pathway Forebrain Development Middle Ear Morphogenesis Muscle Organ Morphogenesis Embryonic Skeletal System Morphogenesis	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Adult Locomotory Behavior Anatomical Structure Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Regulation Of Blood Coagulation Endocrine Pancreas Development Negative Regulation Of Glucokinase Activity Positive Regulation Of Embryonic Development Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation Negative Regulation Of Detection Of Glucose
Pathways			Regulation of gene expression in beta cells
Drugs
Diseases
GWAS		Chin dimples ( 27182965) Male-pattern baldness ( 28196072) Nonsyndromic cleft lip with cleft palate ( 28232668) Nose size ( 27182965)	Adolescent idiopathic scoliosis ( 25784220) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Body size at age 10 ( 32376654) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374 20152958) Gout ( 22179738) Hypothyroidism ( 27182965) Male-pattern baldness ( 22693459 27182965) Monobrow ( 27182965) Type 2 diabetes ( 30054458 32499647) Vitamin D levels ( 26704534)
Interacting Genes		4 interacting genes: FOXA2 SMAD1 SMAD2 SMAD3	9 interacting genes: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTX2 TLE1
Entrez ID		145258	3170
HPRD ID		15928	02618
Ensembl ID		ENSG00000133937	ENSG00000125798
Uniprot IDs		P56915	B0ZTD4 Q9Y261
PDB IDs		2DMU	5X07
Enriched GO Terms of Interacting Partners?
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