APAF1 and DZIP1

Data Source:
BioGRID (biochemical)

		APAF1	DZIP1
Description		apoptotic peptidase activating factor 1	DAZ interacting zinc finger protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytoplasm Centriole Cytosol Centriolar Satellite Ciliary Basal Body Ciliary Transition Fiber
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding	Protein Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Kidney Development Neural Tube Closure Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Aging Response To Nutrient Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cardiac Muscle Cell Apoptotic Process Cell Differentiation Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Neutrophil Degranulation Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of G0 To G1 Transition Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway	Smoothened Signaling Pathway Multicellular Organism Development Germ Cell Development Spermatogenesis Regulation Of Protein Binding Establishment Of Protein Localization Positive Regulation Of Cilium Assembly Cytoplasmic Sequestering Of Protein Cilium Assembly Protein Localization To Cilium
Pathways		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity	Hedgehog 'on' state
Drugs		ATP
Diseases
GWAS			Glomerular filtration rate (cystatin C) ( 26831199) Response to statins (LDL cholesterol change) ( 25350695)
Interacting Genes		18 interacting genes: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 PPP1CA TOP1 TRIAP1	9 interacting genes: DAZ1 DAZ4 LUC7L2 MOS OPTN PPP1R18 PPP2R5A PRPF40A TNS2
Entrez ID		317	22873
HPRD ID		03755	16363
Ensembl ID		ENSG00000120868	ENSG00000134874
Uniprot IDs		O14727	B3KSP1 Q86YF9
PDB IDs		1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE
Enriched GO Terms of Interacting Partners?
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