HMGN1 and RPS6KA4

Data Source:
HPRD (in vitro, in vivo)

		HMGN1	RPS6KA4
Description		high mobility group nucleosome binding domain 1	ribosomal protein S6 kinase A4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding Nucleosomal DNA Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Transcription-coupled Nucleotide-excision Repair Chromatin Organization Positive Regulation Of DNA-templated Transcription, Elongation	Negative Regulation Of Cytokine Production Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Histone Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Phosphorylation Positive Regulation Of Histone Acetylation Intracellular Signal Transduction Histone H3-S10 Phosphorylation Histone H3-S28 Phosphorylation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER	Recycling pathway of L1
Drugs			Flavin mononucleotide
Diseases
GWAS		LDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Leprosy ( 22019778) Offspring birth weight ( 31043758) Primary biliary cholangitis ( 21399635) Primary biliary cirrhosis ( 22961000) Psoriasis ( 23143594) Serum uric acid levels ( 32514006)
Interacting Genes		21 interacting genes: CDC42 CHEK2 EP300 HMGN2 HPF1 IRF2 LIG4 MDM2 NFE2 PARP1 PPP1CC PRKACA PRKACG PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ	9 interacting genes: ATF1 CREB1 FOS HMGN1 MAP2K1 MAPK1 MAPK14 MAPK3 NEDD4
Entrez ID		3150	8986
HPRD ID		01231	04677
Ensembl ID		ENSG00000205581	ENSG00000162302
Uniprot IDs		P05114 Q6NSG7	A0PJF8 B4DPV1 E9PJN1 O75676
PDB IDs
Enriched GO Terms of Interacting Partners?
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