HLCS and TGM3

Data Source:
HPRD (in vivo)

		HLCS	TGM3
Description		holocarboxylase synthetase	transglutaminase 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding	Protein-glutamine Gamma-glutamyltransferase Activity Catalytic Activity Structural Molecule Activity Calcium Ion Binding Transferase Activity, Transferring Acyl Groups
	Biological Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Protein Phosphopantetheinylation Response To Biotin Histone Biotinylation	Cellular Protein Modification Process Peptide Cross-linking Protein Phosphopantetheinylation Keratinocyte Differentiation Hair Follicle Morphogenesis Keratinization Cell Envelope Organization
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		Biotin	5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Monophosphate B-2-Octylglucoside Guanosine-5'-Diphosphate
Diseases		Holocarboxylase synthetase deficiency
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)	Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Inflammatory skin disease ( 25574825) Keratinocyte cancer (MTAG) ( 31174203) Metabolite levels ( 23823483) Non-melanoma skin cancer ( 29739929)
Interacting Genes		8 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 SNX27 SPATA46	2 interacting genes: CALML5 UCHL5
Entrez ID		3141	7053
HPRD ID		08360	02584
Ensembl ID		ENSG00000159267	ENSG00000125780
Uniprot IDs		P50747	Q08188
PDB IDs			1L9M 1L9N 1NUD 1NUF 1NUG
Enriched GO Terms of Interacting Partners?
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