ACACA and MPHOSPH9

Data Source:
BioGRID (two hybrid)

		ACACA	MPHOSPH9
Description		acetyl-CoA carboxylase alpha	M-phase phosphoprotein 9
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Cytosol Actin Cytoskeleton	Golgi Membrane Golgi Apparatus Centriole Membrane
	Molecular Function	Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Tissue Homeostasis Acetyl-CoA Metabolic Process Fatty Acid Biosynthetic Process Carnitine Shuttle Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cholesterol Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Protein Homotetramerization Lipid Homeostasis Cellular Response To Prostaglandin E Stimulus Malonyl-CoA Biosynthetic Process
Pathways		ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine metabolism Activation of gene expression by SREBF (SREBP) Defective HLCS causes multiple carboxylase deficiency Fatty acyl-CoA biosynthesis
Drugs		Biotin
Diseases
GWAS		Ovarian cancer ( 23535730)	Albumin-globulin ratio ( 29403010) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Educational attainment ( 25201988) Intelligence (MTAG) ( 29326435) Multiple sclerosis ( 19525953) Plasma anti-thyroglobulin levels ( 29678681) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Tourette syndrome ( 30818990) Type 2 diabetes ( 24509480 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Venous thromboembolism ( 31420334)
Interacting Genes		11 interacting genes: APOC1 ATXN1 BRCA1 CHGB CSNK2A1 CSNK2A2 FGF14 PRKAA1 PRKAA2 PRKAB1 PRKAG1	3 interacting genes: SVIL YWHAG YWHAZ
Entrez ID		31	10198
HPRD ID		01938	12022
Ensembl ID		ENSG00000278540	ENSG00000051825
Uniprot IDs		A0A024R0Y2 Q13085 Q7Z5W8	Q99550
PDB IDs		2YL2 3COJ 4ASI 6G2D 6G2H 6G2I
Enriched GO Terms of Interacting Partners?
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