DNTTIP2 and H2BC1

Data Source:
BioGRID (pull down)

		DNTTIP2	H2BC1
Description		deoxynucleotidyltransferase terminal interacting protein 2	H2B clustered histone 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus	Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Extrinsic Component Of Plasma Membrane
	Molecular Function	RNA Binding Protein Binding	Molecular_function DNA Binding Histone Binding Protein Heterodimerization Activity
	Biological Process		Nucleosome Assembly Nucleosome Disassembly Inflammatory Response Protein Ubiquitination Plasminogen Activation Spermatogenesis, Exchange Of Chromosomal Proteins Positive Regulation Of Binding Mononuclear Cell Migration
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS		Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome ( 31991592)
Interacting Genes		16 interacting genes: CAVIN1 CEP70 DNTT ESR1 ESR2 H2AW H2BC1 H3C15 H4-16 PCNA PICK1 PPARG RNF8 RXRA SPP1 TULP3	8 interacting genes: ANP32B APP CCNA1 DNTTIP2 H2AC20 HDAC3 SET USP44
Entrez ID		30836	255626
HPRD ID		09994	11024
Ensembl ID		ENSG00000067334	ENSG00000146047
Uniprot IDs		Q5QJE6	Q96A08
PDB IDs			3WKJ 5GSU 5GT3 6BIY
Enriched GO Terms of Interacting Partners?
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