PLA2G2E and MALL

Data Source:
BioGRID (two hybrid)

		PLA2G2E	MALL
Description		phospholipase A2 group IIE	mal, T cell differentiation protein like
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm	Golgi Membrane Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft
	Molecular Function	Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Inflammatory Response Lipid Catabolic Process Low-density Lipoprotein Particle Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Arachidonic Acid Secretion	Myelination Cholesterol Homeostasis
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs		Aminosalicylic acid 1,4-Butanediol N-Tridecanoic Acid 9-Hydroxy-8-Methoxy-6-Nitro-Phenanthrol[3,4-D][1,3]Dioxole-5-Carboxylic Acid Indolepropionic acid P-Anisic Acid Oxyphenbutazone Licofelone Nimesulide (R)-Atenolol (2E)-1-[2-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one Indoleacetic acid (2-CARBAMOYLMETHYL-5-PROPYL-OCTAHYDRO-INDOL-7-YL)ACETIC ACID 3-{3-[(DIMETHYLAMINO)METHYL]-1H-INDOL-7-YL}PROPAN-1-OL Glycerin
Diseases
GWAS		group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Ulcerative colitis ( 19915572 20228799 19122664 23511034)
Interacting Genes		1 interacting genes: MALL	68 interacting genes: AMIGO1 AQP6 ARL13B ATP5PF BEST2 BNIP3 BNIP3L BRI3 BSCL2 CAV1 CAV2 CD79A CLDN7 CLDN9 CLEC10A CLEC12B CLEC14A CPLX4 CREB3 CREB3L1 CRHR2 CTLA4 DAGLA DCBLD2 ELOVL2 ELOVL4 EMP1 EVI2A FCGR1A FFAR2 FNDC9 GGT7 GJA8 GPA33 IL7R KASH5 KLRC1 LDLRAD1 LEPROTL1 LMNA MANBAL MCEMP1 MS4A12 MSR1 MUC1 OPRM1 PGRMC2 PLA2G2E RETREG3 RNF185 SIGLEC6 SIT1 SLC10A1 SLC10A6 SLC18A1 SLC35C2 STMN4 STX1A SYNE4 SYT2 TMEM139 TMEM182 TMEM248 TMEM31 TMEM80 TMX2 UBE2I ZP3
Entrez ID		30814	7851
HPRD ID		07143	15997
Ensembl ID		ENSG00000188784	ENSG00000144063
Uniprot IDs		Q9NZK7	Q13021
PDB IDs		5WZM 5WZO 5WZS 5WZT 5WZU 5WZV 5WZW 5Y5E 6KQU
Enriched GO Terms of Interacting Partners?
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