HCRTR2 and CD200

Data Source:
HPRD (in vivo)

		HCRTR2	CD200
Description		hypocretin receptor 2	CD200 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Synapse	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Axon Neuron Projection Neuronal Cell Body Cell Body
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity Orexin Receptor Activity Peptide Hormone Binding	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Glycosylated Region Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Circadian Sleep/wake Cycle, Wakefulness Circadian Sleep/wake Cycle Process Regulation Of Cytosolic Calcium Ion Concentration	Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Population Proliferation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Positive Regulation Of CREB Transcription Factor Activity Heterotypic Cell-cell Adhesion Negative Regulation Of Macrophage Activation Regulation Of Immune Response Positive Regulation Of Transforming Growth Factor Beta Production Cell-cell Adhesion Positive Regulation Of Arginase Activity Positive Regulation Of Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Neuron Death Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Macrophage Migration Negative Regulation Of T Cell Migration
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Suvorexant Lemborexant
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Chronotype ( 30696823 27494321) Excessive daytime sleepiness ( 27992416) Fasting glucose change (long-term) ( 31263163) HIV-1 control ( 20041166) Menarche (age at onset) ( 25231870) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600 27494321) Severity of nausea and vomiting of pregnancy ( 29563502) Sleep duration (short sleep) ( 30846698) Sleep traits (multi-trait analysis) ( 27992416)	Blood protein levels ( 30072576) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		2 interacting genes: CD200 HCRT	3 interacting genes: CD200R1 HCRTR2 HUS1
Entrez ID		3062	4345
HPRD ID		08374	01124
Ensembl ID		ENSG00000137252	ENSG00000091972
Uniprot IDs		O43614 S4X0W3	B4DDZ6 F8W7G1 P41217
PDB IDs		4S0V 5WQC 5WS3 6TPG 6TPJ 6TPN
Enriched GO Terms of Interacting Partners?
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