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HARS1 and RPL5
Data Source:
HPRD
(in vivo, in vitro)
HARS1
RPL5
Description
histidyl-tRNA synthetase 1
ribosomal protein L5
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Cytosol
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endoplasmic Reticulum
Cytosol
Focal Adhesion
Membrane
Cytosolic Large Ribosomal Subunit
Protein-containing Complex
Extracellular Exosome
Ribonucleoprotein Complex
Molecular Function
Histidine-tRNA Ligase Activity
ATP Binding
Identical Protein Binding
Protein Homodimerization Activity
RNA Binding
MRNA 3'-UTR Binding
Structural Constituent Of Ribosome
Protein Binding
5S RRNA Binding
Ubiquitin Protein Ligase Binding
MRNA 5'-UTR Binding
Ubiquitin Ligase Inhibitor Activity
Biological Process
Translation
TRNA Aminoacylation For Protein Translation
Histidyl-tRNA Aminoacylation
Mitochondrial Translation
Ribosomal Large Subunit Assembly
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
RRNA Processing
Translation
Translational Initiation
SRP-dependent Cotranslational Protein Targeting To Membrane
Positive Regulation Of Gene Expression
Viral Transcription
Ribosomal Large Subunit Biogenesis
Positive Regulation Of Translation
Protein Stabilization
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Ubiquitin Protein Ligase Activity
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Protein Neddylation
Pathways
Cytosolic tRNA aminoacylation
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Histidine
Diseases
Diamond-Blackfan anemia (DBA)
GWAS
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Height (
20881960
)
Mean corpuscular hemoglobin (
32888494
)
Mean reticulocyte volume (
32888494
)
Multiple sclerosis (
19525955
17660530
)
Interacting Genes
7 interacting genes:
EEF1B2
EEF1G
MTNR1B
PSMC5
RPL5
TARS1
TNIK
25 interacting genes:
CLK1
CSNK2A1
CSNK2B
DCC
EIF5A
ERCC6
HARS1
IPO13
IPO5
IPO7
KPNB1
MAP3K14
MDM2
NVL
PDCD4
PPM1D
RNA5S7
SPIN1
SPP1
TNIP1
TNPO1
TP73
TSC22D1
UPF2
VHL
Entrez ID
3035
6125
HPRD ID
00827
04699
Ensembl ID
ENSG00000170445
ENSG00000122406
Uniprot IDs
B4DDD8
B4E1C5
P12081
A2RUM7
P46777
PDB IDs
1X59
2LW7
4G84
4G85
4PHC
4X5O
5W6M
6O76
4UG0
4V6X
5AJ0
5LKS
5T2C
6EK0
6IP5
6IP6
6IP8
6LQM
6LSR
6LSS
6LU8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6W6L
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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