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HARS1 and PSMC5
Data Source:
BioGRID
(two hybrid)
HARS1
PSMC5
Description
histidyl-tRNA synthetase 1
proteasome 26S subunit, ATPase 5
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Cytosol
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Inclusion Body
Proteasome Accessory Complex
Cytoplasmic Vesicle
Nuclear Proteasome Complex
Cytosolic Proteasome Complex
Extracellular Exosome
Blood Microparticle
Postsynapse
Molecular Function
Histidine-tRNA Ligase Activity
ATP Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Binding
ATP Binding
Transcription Factor Binding
ATPase Activity
TBP-class Protein Binding
Thyrotropin-releasing Hormone Receptor Binding
Biological Process
Translation
TRNA Aminoacylation For Protein Translation
Histidyl-tRNA Aminoacylation
Mitochondrial Translation
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Negative Regulation Of Programmed Cell Death
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Inclusion Body Assembly
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Cytosolic tRNA aminoacylation
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Histidine
Diseases
GWAS
Interacting Genes
7 interacting genes:
EEF1B2
EEF1G
MTNR1B
PSMC5
RPL5
TARS1
TNIK
80 interacting genes:
AKT1
AZIN2
BACH2
BFSP2
CAMK2A
CCDC136
CDC42
CFAP206
EPHA8
ERCC3
ERCC6
ESR1
ESR2
ESRRA
ESRRG
FOS
GTF2B
HARS1
HNF4G
HOMER3
HSPA1A
HTT
INSIG2
KRT15
KRT27
KRT31
KRT38
KRT40
LAMB1
LAMC1
MDM2
MYO18B
NR1H3
NR1I2
NR1I3
NR3C2
PDC
PDCL
PLEKHO1
PPARD
PRKN
PSMC1
PSMC2
PSMC3
PSMC4
PSMC6
PSMD11
PSMD12
RAD23A
RARA
RARB
RARG
RORA
RORB
RORC
RXRA
SCOC
SHOC2
SIRPA
SKA1
SP1
SSNA1
SUMO2
TAF10
TFIP11
THAP11
THRB
TNNI2
TNNI3
TNNT1
TP53
TPM1
TPM3
TRIP11
UBC
UBE3C
UBLCP1
USP4
VDR
VIM
Entrez ID
3035
5705
HPRD ID
00827
03400
Ensembl ID
ENSG00000170445
ENSG00000087191
Uniprot IDs
B4DDD8
B4E1C5
P12081
A0A140VJS3
P62195
PDB IDs
1X59
2LW7
4G84
4G85
4PHC
4X5O
5W6M
6O76
2KRK
3KW6
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
Enriched GO Terms of Interacting Partners
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