GUCY2D and GUCA2B

Data Source:
HPRD (in vivo)

		GUCY2D	GUCA2B
Description		guanylate cyclase 2D, retinal	guanylate cyclase activator 2B
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Nuclear Outer Membrane Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane	Extracellular Region Extracellular Exosome
	Molecular Function	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Signaling Receptor Activity Protein Homodimerization Activity	Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Guanylate Cyclase Activator Activity
	Biological Process	CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway Visual Perception Regulation Of Rhodopsin Mediated Signaling Pathway Intracellular Signal Transduction	Digestion Excretion CGMP-mediated Signaling Positive Regulation Of Guanylate Cyclase Activity
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	Digestion
Drugs
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Refractive error ( 32231278)	Apolipoprotein A1 levels ( 32203549)
Interacting Genes		5 interacting genes: GUCA1A GUCA1B GUCA2B RGS9 S100B	3 interacting genes: GUCY2D UBQLN1 UBQLN2
Entrez ID		3000	2981
HPRD ID		02550	03170
Ensembl ID		ENSG00000132518	ENSG00000044012
Uniprot IDs		Q02846	Q16661
PDB IDs		1AWL	1UYA 1UYB
Enriched GO Terms of Interacting Partners?
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