GUCA2B and GUCY2D

Data Source:
HPRD (in vivo)

		GUCA2B	GUCY2D
Description		guanylate cyclase activator 2B	guanylate cyclase 2D, retinal
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GO Annotations	Cellular Component	Extracellular Region Extracellular Exosome	Photoreceptor Outer Segment Nuclear Outer Membrane Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane
	Molecular Function	Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Guanylate Cyclase Activator Activity	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Signaling Receptor Activity Protein Homodimerization Activity
	Biological Process	Digestion Excretion CGMP-mediated Signaling Positive Regulation Of Guanylate Cyclase Activity	CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway Visual Perception Regulation Of Rhodopsin Mediated Signaling Pathway Intracellular Signal Transduction
Pathways		Digestion	Inactivation, recovery and regulation of the phototransduction cascade
Drugs
Diseases			Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Apolipoprotein A1 levels ( 32203549)	Refractive error ( 32231278)
Interacting Genes		3 interacting genes: GUCY2D UBQLN1 UBQLN2	5 interacting genes: GUCA1A GUCA1B GUCA2B RGS9 S100B
Entrez ID		2981	3000
HPRD ID		03170	02550
Ensembl ID		ENSG00000044012	ENSG00000132518
Uniprot IDs		Q16661	Q02846
PDB IDs		1UYA 1UYB	1AWL
Enriched GO Terms of Interacting Partners?
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