APEX2 and TSHZ3

Data Source:
BioGRID (two hybrid)

		APEX2	TSHZ3
Description		apurinic/apyrimidinic endodeoxyribonuclease 2	teashirt zinc finger homeobox 3
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Mitochondrion Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm Plasma Membrane Growth Cone
	Molecular Function	DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Phosphodiesterase I Activity Protein Binding Zinc Ion Binding Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Metal Ion Binding
	Biological Process	Base-excision Repair DNA Recombination Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation
Pathways
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Chronotype ( 30696823) Cognitive performance ( 19734545) Corneal astigmatism ( 30306274) Diastolic blood pressure ( 27841878) Falling risk ( 32999390) FEV1 ( 30804560) Fractional exhaled nitric oxide (childhood) ( 24315451) General risk tolerance (MTAG) ( 30643258) Lung function (FEV1/FVC) ( 30061609 30804560) Peak expiratory flow ( 30804560) Photic sneeze reflex ( 27182965) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Post bronchodilator FEV1 in COPD ( 26634245) Refractive error ( 32231278) Systemising ( 31508503) Systolic blood pressure ( 27841878) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		17 interacting genes: APP CALCOCO2 CCDC85B DAPK1 EFEMP2 HOOK2 LRRK2 MAP3K1 MFHAS1 MKRN3 NEDD4L NINL PCNA PGR TRAF2 TRIM37 TSHZ3	30 interacting genes: ANKRA2 APBB1 APEX2 CCHCR1 CEP63 CEP70 COG6 CTBP1 CTBP2 GOLGA2 HSF2BP KASH5 KRT31 KRT40 LRRC73 MAD1L1 MRPL28 MTUS2 PIBF1 RINT1 ROPN1 SPAG5 TAX1BP1 TEPSIN TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TSC1
Entrez ID		27301	57616
HPRD ID		06442	18351
Ensembl ID		ENSG00000169188	ENSG00000121297
Uniprot IDs		B4DWI9 B7ZA71 E5KN95 Q9UBZ4	Q63HK5
PDB IDs			2DMI
Enriched GO Terms of Interacting Partners?
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