EEF2K and MAPK13

Data Source:
HPRD (in vivo, in vitro)

		EEF2K	MAPK13
Description		eukaryotic elongation factor 2 kinase	mitogen-activated protein kinase 13
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Postsynaptic Density Dendritic Spine	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Elongation Factor-2 Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Translation Factor Activity, RNA Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Response To Ischemia Translational Elongation Regulation Of Protein Autophosphorylation Cellular Response To Insulin Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Protein Autophosphorylation Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Anoxia Cellular Response To Brain-derived Neurotrophic Factor Stimulus Response To Prolactin	Response To Osmotic Stress Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Interleukin-6 Production Cellular Response To UV Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Sorbitol Cellular Response To Anisomycin Cellular Response To Sodium Arsenite
Pathways		mTORC1-mediated signalling	NOD1/2 Signaling Pathway p38MAPK events DSCAM interactions VEGFA-VEGFR2 Pathway
Drugs			Minocycline KC706 Fostamatinib
Diseases
GWAS		Heel bone mineral density ( 30598549)	Birth weight ( 31043758) Blood protein levels ( 30072576 29875488) Offspring birth weight ( 31043758)
Interacting Genes		17 interacting genes: CDK1 EEF2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 PRKAA1 PRKAA2 PRKACA RPS6KA1 RPS6KB1 RPS6KB2	16 interacting genes: AKIP1 ANKLE2 APP ATF2 EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4 SQSTM1
Entrez ID		29904	5603
HPRD ID		07369	09113
Ensembl ID		ENSG00000103319	ENSG00000156711
Uniprot IDs		O00418	A0A024RD04 O15264
PDB IDs		5J8H 5KS5 6NX4	3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO
Enriched GO Terms of Interacting Partners?
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