EEF2K and EEF2

Data Source:
HPRD (in vitro)

		EEF2K	EEF2
Description		eukaryotic elongation factor 2 kinase	eukaryotic translation elongation factor 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Postsynaptic Density Dendritic Spine	Extracellular Region Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Aggresome Secretory Granule Lumen Polysomal Ribosome Membrane Raft Synapse Extracellular Exosome Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Protein Kinase Activity Elongation Factor-2 Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Translation Factor Activity, RNA Binding	P53 Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding 5S RRNA Binding Protein Kinase Binding Ribosome Binding Cadherin Binding Actin Filament Binding
	Biological Process	Response To Ischemia Translational Elongation Regulation Of Protein Autophosphorylation Cellular Response To Insulin Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Protein Autophosphorylation Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Anoxia Cellular Response To Brain-derived Neurotrophic Factor Stimulus Response To Prolactin	Hematopoietic Progenitor Cell Differentiation Response To Ischemia Skeletal Muscle Contraction Translational Elongation Aging Glial Cell Proliferation Response To Estradiol Response To Endoplasmic Reticulum Stress Skeletal Muscle Cell Differentiation Response To Drug Response To Hydrogen Peroxide Neutrophil Degranulation Response To Ethanol Positive Regulation Of Translation Response To Folic Acid Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Cytoplasmic Translation
Pathways		mTORC1-mediated signalling	Peptide chain elongation Peptide chain elongation Uptake and function of diphtheria toxin Synthesis of diphthamide-EEF2 Synthesis of diphthamide-EEF2 Neutrophil degranulation Protein methylation
Drugs			Adenosine-5-Diphosphoribose Diphthamide Guanosine-5'-Diphosphate N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Esketamine Moxetumomab Pasudotox
Diseases
GWAS		Heel bone mineral density ( 30598549)
Interacting Genes		17 interacting genes: CDK1 EEF2 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 PRKAA1 PRKAA2 PRKACA RPS6KA1 RPS6KB1 RPS6KB2	21 interacting genes: CCT2 CDKN2A DISC1 DUX4 EEF2K EP300 ESR1 HNRNPD LINC01554 MAPKAPK3 MLH1 NDRG1 PPM1A PPP2CA PPP2R1A PPP2R1B PTEN SUMO2 TP53 TRPM7 UCHL5
Entrez ID		29904	1938
HPRD ID		07369	00561
Ensembl ID		ENSG00000103319	ENSG00000167658
Uniprot IDs		O00418	A0A384N6H1 P13639
PDB IDs		5J8H 5KS5 6NX4	4V6X 6D9J 6Z6M 6Z6N
Enriched GO Terms of Interacting Partners?
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