GUSB and CES1

Data Source:
HPRD (in vivo, in vitro)

		GUSB	CES1
Description		glucuronidase beta	carboxylesterase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Lipid Droplet Cytosol
	Molecular Function	Beta-glucuronidase Activity Signaling Receptor Binding Protein Domain Specific Binding Carbohydrate Binding	Sterol Esterase Activity Triglyceride Lipase Activity Methylumbelliferyl-acetate Deacetylase Activity Carboxylic Ester Hydrolase Activity Methyl Indole-3-acetate Esterase Activity
	Biological Process	Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Glucuronoside Catabolic Process Hyaluronan Catabolic Process Neutrophil Degranulation	Angiotensin Maturation Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Cholesterol Metabolic Process Response To Toxic Substance Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Lipid Catabolic Process Epithelial Cell Differentiation Cholesterol Homeostasis Reverse Cholesterol Transport Medium-chain Fatty Acid Metabolic Process Regulation Of Bile Acid Biosynthetic Process Cellular Response To Cholesterol Cellular Response To Low-density Lipoprotein Particle Stimulus Cholesterol Ester Hydrolysis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Bile Acid Secretion
Pathways		HS-GAG degradation Hyaluronan uptake and degradation MPS VII - Sly syndrome Neutrophil degranulation	Metabolism of Angiotensinogen to Angiotensins Phase I - Functionalization of compounds
Drugs			Tacrine Meperidine Levocarnitine Dextropropoxyphene Cocaine Naloxone Diamorphine Probucol Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester Cholic Acid 4-Piperidino-Piperidine N-acetyl-alpha-neuraminic acid Thenoyltrifluoroacetone Cyclandelate Avasimibe (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL
Diseases		Mucopolysaccharidosis type VII (MPS7); Sly syndrome
GWAS			Response to dabigatran etexilate treatment ( 23467860)
Interacting Genes		3 interacting genes: CES1 GIT2 PRKACA	10 interacting genes: BMPR2 CREB3 CYSRT1 GORAB GUSB KPRP PDZK1IP1 PLSCR4 SAR1A VENTX
Entrez ID		2990	1066
HPRD ID		02018	00268
Ensembl ID		ENSG00000169919	ENSG00000198848
Uniprot IDs		P08236	P23141
PDB IDs		1BHG 3HN3	1MX1 1MX5 1MX9 1YA4 1YA8 1YAH 1YAJ 2DQY 2DQZ 2DR0 2H7C 2HRQ 2HRR 3K9B 4AB1 5A7F 5A7G 5A7H
Enriched GO Terms of Interacting Partners?
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