GPSM2 and GNAI1

Data Source:
HPRD (in vitro, in vivo)

		GPSM2	GNAI1
Description		G protein signaling modulator 2	G protein subunit alpha i1
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cell Cortex Lateral Plasma Membrane Protein-containing Complex Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Membrane Raft Extracellular Exosome Cell Cortex Region
	Molecular Function	Nucleotide Binding GDP-dissociation Inhibitor Activity Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Self-association Dynein Complex Binding	Magnesium Ion Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Spindle Organization G Protein-coupled Receptor Signaling Pathway Ran Protein Signal Transduction Regulation Of Catalytic Activity Cell Division Maintenance Of Centrosome Location Regulation Of Mitotic Spindle Organization Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Spindle Assembly	Protein Folding Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Regulation Of CAMP-mediated Signaling Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Mitotic Spindle Organization Cellular Response To Forskolin Positive Regulation Of Protein Localization To Cell Cortex
Pathways		G alpha (i) signalling events	PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs			Guanosine-5'-Diphosphate Tetrafluoroaluminate Ion
Diseases
GWAS		Fat distribution (HIV) ( 21897333)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		13 interacting genes: AGR2 ARHGEF40 GAS2L1 GLIS2 GNAI1 GNAI2 GNAI3 GNAO1 HRAS INSC LRRC8E NUMA1 WHRN	62 interacting genes: ADCY5 ADRA2A ADRB2 CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 DRD4 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GNG2 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PCP2 PDE6D PTEN PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1
Entrez ID		29899	2770
HPRD ID		06609	00756
Ensembl ID		ENSG00000121957	ENSG00000127955
Uniprot IDs		A0A024R0F8 B4DIF1 P81274	P63096
PDB IDs		3SF4 4WND 4WNE 4WNF 4WNG 5A6C 6HC2	1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q 5JS7 5JS8 5TDH 6CMO 6CRK 6DDE 6DDF 6KPF 6KPG 6LFM 6LFO 6LML 6N4B 6OMM 6OS9 6OSA 6OT0 6PB0 6PB1 6PT0 6QNO 6VU8 6XBJ 6XBK 6XBL 6XBM
Enriched GO Terms of Interacting Partners?
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