ICOS and TNP1

Data Source:
BioGRID (affinity chromatography technology)

		ICOS	TNP1
Description		inducible T cell costimulator	transition protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane	Nucleosome Male Germ Cell Nucleus Nucleus
	Molecular Function	Protein Binding	DNA Binding Protein Binding
	Biological Process	T Cell Tolerance Induction Immune Response T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Cell-cell Adhesion	Single Strand Break Repair Nucleosome Disassembly Chromatin Remodeling Chromatin Silencing Multicellular Organism Development Spermatid Development Spermatid Nucleus Differentiation Spermatid Nucleus Elongation Positive Regulation Of Protein Processing Sexual Reproduction Flagellated Sperm Motility Fertilization, Exchange Of Chromosomal Proteins Spermatogenesis, Exchange Of Chromosomal Proteins Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate ( 29403010) Height ( 25282103 31562340) Hypothyroidism ( 27182965) Mitral valve prolapse ( 26301497) Permanent tooth development ( 21931568) Pulse pressure ( 27841878) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1	10 interacting genes: CSNK2A1 DVL3 PPARA PPARD PPARG PRKACA PRKACB PRKACG PRKCA SDCBP2
Entrez ID		29851	7141
HPRD ID		09196	01830
Ensembl ID		ENSG00000163600	ENSG00000118245
Uniprot IDs		Q53QY6 Q9Y6W8	P09430 Q4ZG82
PDB IDs		6X4G 7JOO
Enriched GO Terms of Interacting Partners?
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