ICOS and ICOSLG

Data Source:
HPRD (in vitro)

		ICOS	ICOSLG
Description		inducible T cell costimulator	inducible T cell costimulator ligand
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome
	Molecular Function	Protein Binding	Signaling Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	T Cell Tolerance Induction Immune Response T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Cell-cell Adhesion	Regulation Of Cytokine Production Adaptive Immune Response Defense Response Hyperosmotic Response Signal Transduction T Cell Costimulation Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation T Cell Receptor Signaling Pathway
Pathways			Costimulation by the CD28 family
Drugs
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)	Ankylosing spondylitis ( 23749187) Blood protein levels ( 30072576 29875488) Celiac disease ( 22057235 20190752) Cerebral amyloid deposition (PET imaging) ( 30361487) Crohn's disease ( 18587394 21102463) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233) Left ventricular QRS voltage ( 27195777) Rheumatoid arthritis ( 30423114) Type 1 diabetes ( 25751624) Ulcerative colitis ( 21297633)
Interacting Genes		4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1	1 interacting genes: ICOS
Entrez ID		29851	23308
HPRD ID		09196	05757
Ensembl ID		ENSG00000163600	ENSG00000160223
Uniprot IDs		Q53QY6 Q9Y6W8	A0N0L8 B7Z1W8 O75144
PDB IDs		6X4G 7JOO	6X4G 6X4T
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?