GUCA1B and GUCY2D

Data Source:
HPRD (in vitro)

		GUCA1B	GUCY2D
Description		guanylate cyclase activator 1B	guanylate cyclase 2D, retinal
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Plasma Membrane Photoreceptor Disc Membrane Cone Photoreceptor Outer Segment	Photoreceptor Outer Segment Nuclear Outer Membrane Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Signaling Receptor Activity Protein Homodimerization Activity
	Biological Process	Receptor Guanylyl Cyclase Signaling Pathway Cell-cell Signaling Body Fluid Secretion Visual Perception Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Guanylate Cyclase Activity	CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway Visual Perception Regulation Of Rhodopsin Mediated Signaling Pathway Intracellular Signal Transduction
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	Inactivation, recovery and regulation of the phototransduction cascade
Drugs
Diseases		Retinitis pigmentosa (RP)	Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS			Refractive error ( 32231278)
Interacting Genes		3 interacting genes: GUCY2D GUCY2F OTX2	5 interacting genes: GUCA1A GUCA1B GUCA2B RGS9 S100B
Entrez ID		2979	3000
HPRD ID		03783	02550
Ensembl ID		ENSG00000112599	ENSG00000132518
Uniprot IDs		Q7Z3V9 Q9UMX6	Q02846
PDB IDs			1AWL
Enriched GO Terms of Interacting Partners?
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