GUCA1A and GUCY2D

Data Source:
HPRD (in vitro)

		GUCA1A	GUCY2D
Description		guanylate cyclase activator 1A	guanylate cyclase 2D, retinal
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Photoreceptor Disc Membrane Cone Photoreceptor Outer Segment	Photoreceptor Outer Segment Nuclear Outer Membrane Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Guanylate Cyclase Regulator Activity	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Signaling Receptor Activity Protein Homodimerization Activity
	Biological Process	Signal Transduction Visual Perception Phototransduction Positive Regulation Of CGMP-mediated Signaling Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Calcium Ion	CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway Visual Perception Regulation Of Rhodopsin Mediated Signaling Pathway Intracellular Signal Transduction
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	Inactivation, recovery and regulation of the phototransduction cascade
Drugs		Myristic acid
Diseases		Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)	Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Spatial processing ( 31596458)	Refractive error ( 32231278)
Interacting Genes		9 interacting genes: AGR2 C1QTNF5 DDIT4L DEFB118 GSC2 GUCY2D HSPB1 KATNAL1 PRKAR1B	5 interacting genes: GUCA1A GUCA1B GUCA2B RGS9 S100B
Entrez ID		2978	3000
HPRD ID		02648	02550
Ensembl ID		ENSG00000048545	ENSG00000132518
Uniprot IDs		B2R9P6 P43080	Q02846
PDB IDs			1AWL
Enriched GO Terms of Interacting Partners?
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