BRF1 and RLIM

Data Source:
BioGRID (enzymatic study)

		BRF1	RLIM
Description		BRF1 RNA polymerase III transcription initiation factor subunit	ring finger protein, LIM domain interacting
Image		No pdb structure
GO Annotations	Cellular Component	Transcription Factor TFIIIB Complex Nucleus Nucleoplasm Transcription Preinitiation Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex
	Molecular Function	RNA Polymerase III General Transcription Initiation Factor Activity RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Protein Binding TBP-class Protein Binding Metal Ion Binding	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA-templated Transcription, Initiation Transcription By RNA Polymerase III Transcription Initiation From RNA Polymerase III Promoter RRNA Transcription TRNA Transcription Positive Regulation Of Transcription By RNA Polymerase III Transcription Preinitiation Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Random Inactivation Of X Chromosome Regulation Of Dosage Compensation By Inactivation Of X Chromosome
Pathways		RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Huntington's disease progression ( 28642124) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 22139419 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 27863252) Red blood cell count ( 32888494)
Interacting Genes		16 interacting genes: APP CSNK2A1 DTNBP1 GTF3C3 GTF3C4 GTF3C5 PCBD2 POLR3F RB1 RBL1 RBL2 RHOU RLIM TBP TP53 UBC	30 interacting genes: BRF1 ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LNX2 MDM2 PDLIM1 REXO1 RPS14 SIN3A SMAD7 SMURF2 SNX17 SS18L1 STAT6 TERF1 TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2K
Entrez ID		2972	51132
HPRD ID		05361	02304
Ensembl ID		ENSG00000185024	ENSG00000131263
Uniprot IDs		A0A024R6P8 Q92994 V9HVY2	Q9NVW2
PDB IDs			6W7Z 6W9A 6W9D
Enriched GO Terms of Interacting Partners?
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