GTF2E1 and GTF2F1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		GTF2E1	GTF2F1
Description		general transcription factor IIE subunit 1	general transcription factor IIF subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIE Complex Cytosol Transcription Preinitiation Complex	Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIF Complex Cell Junction Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Metal Ion Binding	TFIIF-class Transcription Factor Complex Binding DNA Binding RNA Binding Protein Binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity Phosphatase Activator Activity Protein Phosphatase Binding Protein Domain Specific Binding Promoter-specific Chromatin Binding
	Biological Process	Transcription Open Complex Formation At RNA Polymerase II Promoter Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Viral Process SnRNA Transcription By RNA Polymerase II	MRNA Splicing, Via Spliceosome Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Fibroblast Growth Factor Receptor Signaling Pathway Response To Virus RNA Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter SnRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Regulation Of Catalytic Activity
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Interacting Genes		34 interacting genes: APP CBFA2T2 CDK7 ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 IKBKG NRARP PCBD2 POLR2A SND1 SRPK2 TAF1 TAF11 TAF6 TBC1D21 TBP TCEA1 TLE5 TRIM15 TRIM24 TRIM29 ZBTB9 ZSCAN1	32 interacting genes: ABL1 AHR AR ARNT ATF7IP CCNT1 CDK9 CSNK2A1 CTDP1 CTDSP1 DAPK1 FEZ1 FOS GTF2A1 GTF2B GTF2E1 GTF2E2 GTF2F2 GTF2H4 JUN MAGEC1 MSX2 MYC PARP1 POLR2A PSMC2 PTN SRF TAF1 TAF11 TBP TRIM27
Entrez ID		2960	2962
HPRD ID		01799	01803
Ensembl ID		ENSG00000153767	ENSG00000125651
Uniprot IDs		P29083	P35269
PDB IDs		1VD4 2JTX 2RNQ 2RNR 5GPY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L	1F3U 1I27 1J2X 1NHA 1ONV 2K7L 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L
Enriched GO Terms of Interacting Partners?
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