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MSH6 and BARD1
Data Source:
BioGRID
(pull down, biochemical)
MSH6
BARD1
Description
mutS homolog 6
BRCA1 associated RING domain 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Golgi Apparatus
Cytosol
Mismatch Repair Complex
MutSalpha Complex
Intracellular Membrane-bounded Organelle
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
BRCA1-BARD1 Complex
Cytoplasmic Ribonucleoprotein Granule
BRCA1-A Complex
Molecular Function
Magnesium Ion Binding
Four-way Junction DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Protein Binding
ATP Binding
DNA-dependent ATPase Activity
ATPase Activity
Enzyme Binding
Mismatched DNA Binding
Guanine/thymine Mispair Binding
Single Guanine Insertion Binding
Single Thymine Insertion Binding
Oxidized Purine DNA Binding
MutLalpha Complex Binding
Methylated Histone Binding
Protein Homodimerization Activity
ADP Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Kinase Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
Meiotic Mismatch Repair
DNA Repair
Pyrimidine Dimer Repair
Mismatch Repair
Determination Of Adult Lifespan
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Viral Process
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Recombination Of Immunoglobulin Gene Segments
Interstrand Cross-link Repair
Maintenance Of DNA Repeat Elements
Isotype Switching
Negative Regulation Of DNA Recombination
Positive Regulation Of Helicase Activity
Intrinsic Apoptotic Signaling Pathway
DNA Double-strand Break Processing
Tissue Homeostasis
DNA Replication
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Protein Ubiquitination
Protein Deubiquitination
Negative Regulation Of MRNA 3'-end Processing
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Export From Nucleus
Protein K6-linked Ubiquitination
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Defective Mismatch Repair Associated With MSH2
Defective Mismatch Repair Associated With MSH6
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
UCH proteinases
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Drugs
Diseases
Colorectal cancer
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS
General risk tolerance (MTAG) (
30643258
)
Heel bone mineral density (
30598549
)
Lifetime average cigarettes per day in chronic obstructive pulmonary disease (
21685187
)
Menopause (age at onset) (
26414677
)
Takayasu arteritis (
25604533
)
Tea consumption (
31046077
)
Feeling fed-up (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Neuroblastoma (
22941191
21124317
)
Neuroblastoma (high-risk) (
19412175
)
Neuroblastoma (MYCN amplification) (
28924153
)
Neurociticism (
29500382
)
Sporadic neuroblastoma (
28545128
)
Interacting Genes
18 interacting genes:
BARD1
BRCA1
CHAF1A
CREBBP
CSNK2A1
EP300
HRAS
HUS1
MAP2K1
MSH2
MUTYH
NANS
PCNA
PTEN
RAD1
RAD9A
SMC1A
SUMO2
125 interacting genes:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
AXIN2
BCCIP
BCL3
BRCA1
BRD7
CAP1
CBX1
CBX3
CBX5
CCDC136
CDK1
CDK2
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CSTF1
DCC
DDX39B
DNAI7
ELP1
ESR1
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AC20
H2AX
H2BC21
HAP1
HNRNPC
HNRNPLL
HSF2BP
HSPA14
IDI1
IKZF1
ING5
KAT5
KAT7
KBTBD7
KIFC3
KRT40
LDOC1
LGALS8
LRIF1
MACROH2A1
MAGED1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT-ND1
MT2A
MTUS2
NFKBIA
NPC2
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
PIN1
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RABEP1
RAD51
RBBP8
RBMY2BP
RPS20
SELENBP1
SETDB1
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TERF2
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WDR61
WRN
XRCC6
ZFP64
ZHX1
ZNF121
ZNF655
Entrez ID
2956
580
HPRD ID
07202
03354
Ensembl ID
ENSG00000116062
ENSG00000138376
Uniprot IDs
P52701
Q3SWU9
A0A087WZ19
A0AVN2
C9IYG1
F6MDI0
F6MDI1
F6MDI2
Q99728
PDB IDs
2GFU
2O8B
2O8C
2O8D
2O8E
2O8F
6OQM
1JM7
2NTE
2R1Z
3C5R
3FA2
Enriched GO Terms of Interacting Partners
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