GSTM1 and GSTM2

Data Source:
HPRD (in vitro)

		GSTM1	GSTM2
Description		glutathione S-transferase mu 1	glutathione S-transferase mu 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Intercellular Bridge	Cytoplasm Cytosol Sarcoplasmic Reticulum Intercellular Bridge Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Enzyme Binding Protein Homodimerization Activity Glutathione Binding	Glutathione Transferase Activity Glutathione Peroxidase Activity Signaling Receptor Binding Fatty Acid Binding Protein Binding Enzyme Binding Protein Homodimerization Activity Glutathione Binding
	Biological Process	Prostaglandin Metabolic Process Glutathione Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Hepoxilin Biosynthetic Process Cellular Detoxification Of Nitrogen Compound Glutathione Derivative Biosynthetic Process	Glutathione Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Linoleic Acid Metabolic Process Hepoxilin Biosynthetic Process Relaxation Of Cardiac Muscle Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Detoxification Of Nitrogen Compound Cellular Response To Caffeine Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process
Pathways		Glutathione conjugation	Glutathione conjugation
Drugs		Glutathione Chloroquine (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene Zinc trihydroxide S-(2,4-dinitrophenyl)glutathione Glutathione disulfide 5-fluorotryptophan (9S,10S)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene	Glutathione S-(2,4-dinitrophenyl)glutathione Glutathione disulfide Glutathione disulfide S-Methyl glutathione
Diseases
GWAS		Bladder cancer ( 20972438) Blood protein levels ( 30072576) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Metabolite levels ( 31628463) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		3 interacting genes: GSTM2 GSTM3 MAP3K5	4 interacting genes: GSTM1 GSTM3 GSTM5 PTEN
Entrez ID		2944	2946
HPRD ID		00707	00710
Ensembl ID		ENSG00000134184	ENSG00000213366
Uniprot IDs		P09488 X5D932 X5DR03	A0A384P5E9 P28161 Q0D2I8
PDB IDs		1GTU 1XW6 1XWK 1YJ6 2F3M	1HNA 1HNB 1HNC 1XW5 1YKC 2AB6 2C4J 2GTU 3GTU 3GUR 5HWL
Enriched GO Terms of Interacting Partners?
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