PDIA3 and CACNB2

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, proximity labelling technology, affinity chromatography technology)
HPRD (in vivo)

		PDIA3	CACNB2
Description		protein disulfide isomerase family A member 3	calcium voltage-gated channel auxiliary subunit beta 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Cell Surface Melanosome MHC Class I Peptide Loading Complex Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Calcium Channel Complex Photoreceptor Ribbon Synapse Presynapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Disulfide Oxidoreductase Activity Peptide Disulfide Oxidoreductase Activity Identical Protein Binding	Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Actin Filament Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Folding Proteolysis Protein Phosphopantetheinylation Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-7 Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Chemical Synaptic Transmission Neuromuscular Junction Development Visual Perception Positive Regulation Of Calcium Ion Transport Cardiac Conduction Calcium Ion Import Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Depolarization During AV Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways		ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Presynaptic depolarization and calcium channel opening Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Nicardipine Magnesium sulfate Levomenthol Felodipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Nilvadipine Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases			Brugada syndrome (BRS)
GWAS		Blood protein levels ( 30072576) Lead levels ( 26025379) Triglyceride levels ( 32203549)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Antisaccade task score ( 31596458) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 21909110) Body mass index ( 28892062) Brain volume in infants (grey matter) ( 28763065) Cadmium levels ( 26025379) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 19430479 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hypertension ( 31879980 19430479 21909115) LDL cholesterol levels ( 32203549) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels (HVA/MHPG ratio) ( 23319000) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Protein quantitative trait loci ( 18464913) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Quantitative traits ( 19197348) Response to antiepileptic drugs in genetic generalized epilepsy ( 32308125) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Small vessel stroke ( 26732560) Systolic blood pressure ( 28135244 19430479 27841878 21909115 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		21 interacting genes: APP BACE1 CALR CANX ERO1A ERP27 ESR1 GYPC HLA-A IFNG LGALS9 LINC01554 MDM2 MTNR1B PCAT1 SLC12A3 SLC2A1 STAT3 SUMO4 TAP1 UBE3A	6 interacting genes: CTBP2 HEXIM2 PRKACA PRMT5 REM1 TMEM174
Entrez ID		2923	783
HPRD ID		03625	02473
Ensembl ID		ENSG00000167004	ENSG00000165995
Uniprot IDs		P30101 V9HVY3	A0A494C0B2 A0A494C184 Q08289 Q59H42 Q5VVH1
PDB IDs		2ALB 2DMM 2H8L 3F8U 6ENY
Enriched GO Terms of Interacting Partners?
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