CXCL1 and CXCR1

Data Source:
HPRD (in vivo)

		CXCL1	CXCR1
Description		C-X-C motif chemokine ligand 1	C-X-C motif chemokine receptor 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Specific Granule Lumen Tertiary Granule Lumen	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Chemokine Activity Enzyme Activator Activity Growth Factor Activity CXCR Chemokine Receptor Binding	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Negative Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Neutrophil Chemotaxis Intracellular Signal Transduction Neutrophil Degranulation Regulation Of Catalytic Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Dendritic Cell Chemotaxis Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Degranulation Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs			Ketoprofen
Diseases
GWAS		Anxiety disorder ( 25390645) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Growth-regulated protein alpha levels ( 27989323) Inflammatory bowel disease ( 23128233)	Basophil count ( 32888494) Diffusing capacity of carbon monoxide ( 30694715) Idiopathic intracranial hypertension ( 29608535) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 29403010) Smooth-surface caries ( 23470693) White blood cell count ( 29403010)
Interacting Genes		13 interacting genes: ACKR1 CCL11 CXCL5 CXCL6 CXCR1 CXCR2 ESR1 HIPK2 HRAS MEOX2 MMP9 PTEN XRCC3	20 interacting genes: ADRA1A CDK1 CLDND1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 FATE1 GNA14 GNA15 GNAI2 IGFBP5 PDCD6IP PPBP TRARG1 TUBA1A UBE2C
Entrez ID		2919	3577
HPRD ID		01119	00908
Ensembl ID		ENSG00000163739	ENSG00000163464
Uniprot IDs		P09341	P25024
PDB IDs		1MGS 1MSG 1MSH 1ROD	1ILP 1ILQ 2LNL
Enriched GO Terms of Interacting Partners?
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