CXCL1 and ACKR1

Data Source:
HPRD (in vivo, in vitro)

		CXCL1	ACKR1
Description		C-X-C motif chemokine ligand 1	atypical chemokine receptor 1 (Duffy blood group)
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Specific Granule Lumen Tertiary Granule Lumen	Early Endosome Plasma Membrane Integral Component Of Membrane Recycling Endosome
	Molecular Function	Signaling Receptor Binding Protein Binding Chemokine Activity Enzyme Activator Activity Growth Factor Activity CXCR Chemokine Receptor Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity C-C Chemokine Binding Signaling Receptor Activity
	Biological Process	Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Negative Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Neutrophil Chemotaxis Intracellular Signal Transduction Neutrophil Degranulation Regulation Of Catalytic Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Defense Response Inflammatory Response G Protein-coupled Receptor Signaling Pathway Regulation Of Chemokine Production Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling Neutrophil degranulation	Peptide ligand-binding receptors
Drugs
Diseases
GWAS		Anxiety disorder ( 25390645) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Growth-regulated protein alpha levels ( 27989323) Inflammatory bowel disease ( 23128233)	Eotaxin levels ( 27989323) Growth-regulated protein alpha levels ( 27989323) Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Monocyte chemoattractant protein-1 levels ( 27989323 31217265) Neutrophil level response to clozapine in treatment-resistant schizophrenia ( 30647433)
Interacting Genes		13 interacting genes: ACKR1 CCL11 CXCL5 CXCL6 CXCR1 CXCR2 ESR1 HIPK2 HRAS MEOX2 MMP9 PTEN XRCC3	9 interacting genes: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8 MTNR1B
Entrez ID		2919	2532
HPRD ID		01119	00192
Ensembl ID		ENSG00000163739	ENSG00000213088
Uniprot IDs		P09341	Q16570 Q5Y7A1 Q5Y7A2
PDB IDs		1MGS 1MSG 1MSH 1ROD	4NUU 4NUV
Enriched GO Terms of Interacting Partners?
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