UHRF1 and MBD4

Data Source:
BioGRID (pull down)

		UHRF1	MBD4
Description		ubiquitin like with PHD and ring finger domains 1	methyl-CpG binding domain 4, DNA glycosylase
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GO Annotations	Cellular Component	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Nuclear Matrix	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Nucleosomal Histone Binding Methylated Histone Binding Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Ubiquitin Protein Ligase Activity	DNA Binding Satellite DNA Binding Endodeoxyribonuclease Activity Protein Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA N-glycosylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Cycle Maintenance Of DNA Methylation Histone Monoubiquitination Protein Ubiquitination Histone Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Protein Autoubiquitination Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity	DNA Repair Response To Estradiol Depyrimidination
Pathways		DNA methylation	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1
Drugs
Diseases
GWAS		Birth weight ( 31043758) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Mental health study participation (completed survey) ( 31263887) Systolic blood pressure ( 30578418) Type 2 diabetes ( 30297969) Urate levels ( 31578528)	Diisocyanate-induced asthma ( 25918132) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		26 interacting genes: DNMT1 DNMT3A ERCC1 ERG FANCD2 H2AC4 H2BC3 H3-4 H3C1 H3C13 H3C14 H3C15 H4C14 KAT5 LASP1 LIG1 MBD4 MUS81 PCLAF PCNA PRKACA TP53 UBE2D1 UBE2D3 UBE2N UHRF2	15 interacting genes: CDCA2 CSNK2B DNMT3B FADD FAS HDAC1 KDM1A MLH1 NAT2 SIN3A SUV39H1 TRIM27 TRIM55 TRIM63 UHRF1
Entrez ID		29128	8930
HPRD ID		06992	04654
Ensembl ID		ENSG00000276043	ENSG00000129071
Uniprot IDs		A0A087WVR3 Q96T88	O95243
PDB IDs		2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5 4QQD 5C6D 5IAY 5XPI 5YY9 5YYA 6B9M 6IIW 6VCS 6VED	2MOE 3IHO 4DK9 4E9E 4E9F 4E9G 4E9H 4EA4 4EA5 4LG7 4OFA 4OFE 4OFH 5CHZ
Enriched GO Terms of Interacting Partners?
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