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SUMO1 and WRN
Data Source:
BioGRID
(two hybrid)
SUMO1
WRN
Description
small ubiquitin like modifier 1
WRN RecQ like helicase
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nuclear Pore
Nucleoplasm
Nucleolus
Cytosol
Plasma Membrane
Voltage-gated Potassium Channel Complex
Nuclear Body
PML Body
Nuclear Speck
Nuclear Membrane
Nuclear Stress Granule
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Nucleolus
Cytoplasm
Centrosome
Nuclear Speck
Neuron Projection
Molecular Function
RNA Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Enzyme Binding
Protein Tag
Ubiquitin Protein Ligase Binding
Small Protein Activating Enzyme Binding
Ubiquitin-like Protein Ligase Binding
Ubiquitin-specific Protease Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
Y-form DNA Binding
Bubble DNA Binding
DNA Binding
DNA Helicase Activity
Chromatin Binding
Helicase Activity
Exonuclease Activity
Protein Binding
ATP Binding
3'-5' Exonuclease Activity
Four-way Junction Helicase Activity
ATPase Activity
Manganese Ion Binding
MutLalpha Complex Binding
Protein Homodimerization Activity
3'-5' DNA Helicase Activity
Protein-containing Complex Binding
G-quadruplex DNA Binding
Forked DNA-dependent Helicase Activity
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
3'-flap-structured DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA Repair
Double-strand Break Repair Via Nonhomologous End Joining
Viral Process
Protein Sumoylation
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Cellular Response To Heat
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Action Potential
Negative Regulation Of Transcription, DNA-templated
Protein Stabilization
Roof Of Mouth Development
Regulation Of Interferon-gamma-mediated Signaling Pathway
Cellular Response To Cadmium Ion
Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Synthesis Involved In DNA Repair
DNA Metabolic Process
DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Repair
Base-excision Repair
Double-strand Break Repair
DNA Recombination
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Brain Development
Aging
Cell Aging
Cellular Response To Starvation
Response To UV-C
Multicellular Organism Aging
Replication Fork Processing
DNA Duplex Unwinding
Regulation Of Growth Rate
Regulation Of Apoptotic Process
G-quadruplex DNA Unwinding
Positive Regulation Of Hydrolase Activity
Telomeric D-loop Disassembly
Cellular Response To Gamma Radiation
Nucleic Acid Phosphodiester Bond Hydrolysis
Replicative Senescence
T-circle Formation
Positive Regulation Of Strand Invasion
Regulation Of Signal Transduction By P53 Class Mediator
Protein Localization To Nucleolus
Pathways
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMO E3 ligases SUMOylate target proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
Regulation of IFNG signaling
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
Processive synthesis on the C-strand of the telomere
Removal of the Flap Intermediate from the C-strand
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Drugs
Diseases
Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
GWAS
Chronotype (
30696823
)
Cough in response to angiotensin-converting enzyme inhibitor drugs (
28084903
)
Daytime sleep phenotypes (
27126917
)
Exercise treadmill test traits (
17903301
)
Fasting glucose change (long-term) (
31263163
)
Intelligence (MTAG) (
29326435
)
Lifespan (
25918517
)
Logical memory (delayed recall) in mild cognitive impairment (
29274321
)
Logical memory (immediate recall) in mild cognitive impairment (
29274321
)
Metabolite levels (
23823483
)
Morning person (
30696823
)
Interacting Genes
151 interacting genes:
AR
ATF2
ATXN1
ATXN3
ATXN7
AXIN1
BIRC3
BLM
BRCA1
BTBD3
C11orf65
C18orf25
CANX
CARD9
CASP2
CASP8
CCR2
CDK6
CHAF1A
CHD3
CREBBP
DAXX
DEUP1
DNM1
DNMT3B
DTX2
EDARADD
EGLN3
EIF2AK2
ERCC6
ETV6
FAF1
FAM118B
FAS
FASLG
FBF1
FOS
FOXM1
GMCL1
HDAC4
HDAC9
HGS
HIF1A
HIPK2
HIPK3
HNRNPC
HNRNPK
HSF1
HTT
IKZF3
IRAK1
JUN
MAPK1IP1L
MDM2
MEF2A
MITF
MRE11
MRTFA
MSX1
MTOR
MUL1
MYB
NCOA1
NCOA2
NCOA3
NCOR2
NFE2L2
NFKBIA
NIN
NR3C1
NR3C2
PARK7
PAX6
PCNA
PDGFC
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PKM
PLAGL1
PML
PPM1J
PRKN
PROP1
PSIP1
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RHOXF2
RNF111
RNF167
RNF4
RPS3
SAE1
SALL1
SATB1
SENP1
SENP2
SENP6
SETX
SLC2A1
SOX10
SOX2
SOX6
SP100
SP3
SPOP
SREBF1
SREBF2
SUMO1P1
TDG
TDP2
TFCP2
TMIE
TNFRSF1A
TOE1
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP73
TRAF2
TRAF4
TRAF5
TRIM24
TRPS1
TSC22D3
UBA2
UBE2I
USP25
USPL1
WRN
XPO1
ZBTB16
ZBTB2
ZBTB26
ZBTB6
ZCCHC12
ZCCHC7
ZFP42
ZHX1
ZMYM2
ZMYM3
ZMYM5
ZNF451
33 interacting genes:
ATM
ATRX
BARD1
BLM
BRCA1
CDKN2A
FEN1
H2AX
MDC1
MDM2
PARP1
PCNA
POLB
POLD2
POLK
POLR1C
PRKAR1B
PRKDC
RAD1
RAD51
RAD52
RAD54B
RAD9A
RPA1
SUMO1
SUMO2
TERF2
TP53
UBE2D2
VCP
WRNIP1
XRCC5
XRCC6
Entrez ID
7341
7486
HPRD ID
03554
05212
Ensembl ID
ENSG00000116030
ENSG00000165392
Uniprot IDs
A0A024R3Z2
P63165
Q14191
PDB IDs
1A5R
1TGZ
1WYW
1Y8R
1Z5S
2ASQ
2BF8
2G4D
2IO2
2IY0
2IY1
2KQS
2LAS
2MW5
2N1A
2N1V
2PE6
2UYZ
2VRR
3KYC
3KYD
3RZW
3UIP
4WJN
4WJO
4WJP
4WJQ
5AEK
5B7A
5ELJ
5GHD
6EOP
6EOT
6J4I
6JXU
6JXV
6K5T
6UYO
6UYP
6UYQ
6UYR
6UYS
6UYT
6UYU
6UYV
6UYX
6UYY
6UYZ
6V7P
6V7Q
6V7R
6V7S
6WW3
2AXL
2DGZ
2E1E
2E1F
2FBT
2FBV
2FBX
2FBY
2FC0
3AAF
6TYV
6YHR
Enriched GO Terms of Interacting Partners
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