MCHR1 and PMCH

Data Source:
HPRD (in vitro)

		MCHR1	PMCH
Description		melanin concentrating hormone receptor 1	pro-melanin concentrating hormone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cilium Neuron Projection Ciliary Membrane Non-motile Cilium	Extracellular Region Nucleus Synapse
	Molecular Function	G Protein-coupled Receptor Activity Signaling Receptor Binding Protein C-terminus Binding Neuropeptide Receptor Activity Melanin-concentrating Hormone Receptor Activity Peptide Binding Hormone Binding Neuropeptide Binding	Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Feeding Behavior Positive Regulation Of Calcium Ion Transport	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Multicellular Organism Development Spermatogenesis Behavior Feeding Behavior Cell Differentiation
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events BBSome-mediated cargo-targeting to cilium	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		Haloperidol
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Feeling worry ( 29500382) Large artery stroke ( 28265093) Neurociticism ( 29500382) Refractive error ( 32231278) Schizophrenia ( 28991256)	Adventurousness ( 30643258) Brain morphology (MOSTest) ( 32665545) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 19893584) Number of sexual partners ( 30643258)
Interacting Genes		2 interacting genes: PMCH ZMYND19	10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7
Entrez ID		2847	5367
HPRD ID		11874	01459
Ensembl ID		ENSG00000128285	ENSG00000183395
Uniprot IDs		Q99705	P20382
PDB IDs
Enriched GO Terms of Interacting Partners?
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