SPATA46 and HLCS

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SPATA46	HLCS
Description		spermatogenesis associated 46	holocarboxylase synthetase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Membrane	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Protein Binding	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding
	Biological Process	Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Fertilization Cell Differentiation	Biotin Metabolic Process Protein Biotinylation Histone Modification Protein Phosphopantetheinylation Response To Biotin Histone Biotinylation
Pathways			Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs			Biotin
Diseases			Holocarboxylase synthetase deficiency
GWAS			Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		8 interacting genes: APP CCDC85B CYSRT1 HLCS KRT34 RBPMS TLX3 TRAF1	8 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 SNX27 SPATA46
Entrez ID		284680	3141
HPRD ID		14154	08360
Ensembl ID		ENSG00000171722	ENSG00000159267
Uniprot IDs		Q5T0L3	P50747
PDB IDs
Enriched GO Terms of Interacting Partners?
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