ZNF575 and SPRED2

Data Source:
BioGRID (two hybrid)

		ZNF575	SPRED2
Description		zinc finger protein 575	sprouty related EVH1 domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytosol Plasma Membrane Transport Vesicle Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Inactivation Of MAPK Activity Multicellular Organism Development Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Deacetylation Negative Regulation Of Lens Fiber Cell Differentiation
Pathways			Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases
GWAS			Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Body size at age 10 ( 32376654) Celiac disease or Rheumatoid arthritis ( 21383967) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 33020668) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Gamma glutamyl transferase levels ( 29403010) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 27569725 23128233) Intraocular pressure ( 29617998) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systolic blood pressure ( 31647587) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 30275531) White blood cell count ( 32888494 27863252)
Interacting Genes		26 interacting genes: CARD10 CYSRT1 HAP1 HNRNPK KHDRBS3 KRT40 KRTAP10-7 KRTAP10-8 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP5-1 KRTAP6-3 KRTAP9-2 KRTAP9-3 MAPK8IP3 MDFI MYF5 PICK1 SNX33 SPRED2 TNS2 TP53BP2 TRIM41 ZNF526 ZRANB1	30 interacting genes: AQP1 CTSD KCNIP1 KIT KPRP KRTAP12-2 KRTAP2-3 KRTAP2-4 LCE1C LCE2B LCE5A MDFI MTDH MYO15B NCS1 NDUFB7 QARS1 RBM48 RHOA RPS6KA6 SPG21 TOP3B TSNAX VSNL1 ZDHHC17 ZNF250 ZNF414 ZNF417 ZNF575 ZNF837
Entrez ID		284346	200734
HPRD ID		15854	18100
Ensembl ID		ENSG00000176472	ENSG00000198369
Uniprot IDs		A0A024R0U0 Q86XF7	B3KPL5 Q7Z698
PDB IDs			2JP2
Enriched GO Terms of Interacting Partners?
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