SPRED2 and ZNF837

Data Source:
BioGRID (two hybrid)

		SPRED2	ZNF837
Description		sprouty related EVH1 domain containing 2	zinc finger protein 837
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Transport Vesicle Membrane	Nucleus
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Inactivation Of MAPK Activity Multicellular Organism Development Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Deacetylation Negative Regulation Of Lens Fiber Cell Differentiation	Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Body size at age 10 ( 32376654) Celiac disease or Rheumatoid arthritis ( 21383967) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 33020668) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Gamma glutamyl transferase levels ( 29403010) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 27569725 23128233) Intraocular pressure ( 29617998) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systolic blood pressure ( 31647587) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 30275531) White blood cell count ( 32888494 27863252)
Interacting Genes		30 interacting genes: AQP1 CTSD KCNIP1 KIT KPRP KRTAP12-2 KRTAP2-3 KRTAP2-4 LCE1C LCE2B LCE5A MDFI MTDH MYO15B NCS1 NDUFB7 QARS1 RBM48 RHOA RPS6KA6 SPG21 TOP3B TSNAX VSNL1 ZDHHC17 ZNF250 ZNF414 ZNF417 ZNF575 ZNF837	77 interacting genes: BAHD1 CARD10 CATSPER1 CCDC125 CCDC136 CCNDBP1 CDC37 CHIC2 CLK2 CYSRT1 DHX57 DVL3 EFEMP2 EHMT2 FSD2 GOLGA6L9 GPATCH2L HOXA1 KHDRBS2 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-11 KRTAP4-12 KRTAP4-5 KRTAP5-9 MDFI MTUS2 MYO15B NBPF19 NOTCH2NLA PCSK5 PHF19 PPARD PPP1R37 PRPF31 RBMY1F RBMY1J RSPO2 SPRED2 SPRY1 TCEANC TNS2 TRIM41 TRMT2A UBE2I VWC2 ZBTB24 ZBTB48 ZBTB8A ZNF121 ZNF124 ZNF165 ZNF17 ZNF202 ZNF250 ZNF275 ZNF330 ZNF408 ZNF417 ZNF473 ZNF497 ZNF524 ZNF526 ZNF552 ZNF587 ZNF639 ZNF648 ZNF655 ZNF764 ZNF792 ZNF835 ZRANB1 ZSCAN21
Entrez ID		200734	116412
HPRD ID		18100
Ensembl ID		ENSG00000198369	ENSG00000152475
Uniprot IDs		B3KPL5 Q7Z698	Q96EG3
PDB IDs		2JP2
Enriched GO Terms of Interacting Partners?
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