KANSL1 and TRAF4

Data Source:
BioGRID (two hybrid)

		KANSL1	TRAF4
Description		KAT8 regulatory NSL complex subunit 1	TNF receptor associated factor 4
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Condensed Chromosome Kinetochore Nucleus Nucleoplasm NSL Complex MLL1 Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Perinuclear Region Of Cytoplasm Plasma Membrane Signaling Receptor Complex
	Molecular Function	Protein Binding Histone Acetyltransferase Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding WW Domain Binding
	Biological Process	Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation	Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange By Respiratory System Respiratory Tube Development Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein K63-linked Ubiquitination
Pathways		HATs acetylate histones
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive function ( 28093568) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) General factor of neuroticism ( 30867560) Hand grip strength ( 29313844) Handedness (Left-handed vs. non-left-handed) ( 30980028) Handedness (Right-handed vs. non-right-handed) ( 30980028) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Household income ( 31844048) Idiopathic pulmonary fibrosis ( 24429156) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte percentage of white cells ( 27863252) Macular thickness ( 30535121) Male-pattern baldness ( 27182965 28196072) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 27863252) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Oily fish consumption ( 32066663) Osteoarthrosis (time to event) ( 32589924) Parkinson's disease ( 32201043 31660654 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Plateletcrit ( 32888494) Pork consumption ( 32066663) Pulse pressure ( 27841878) Reaction time ( 29844566) Red blood cell count ( 29403010) Red cell distribution width ( 32888494 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878) Ventral diencephalon volume ( 31530798) White matter integrity (mean diffusivity) ( 32358547)
Interacting Genes		34 interacting genes: CALCOCO2 CCDC136 CCDC85B CDC5L CDR2 CEP70 DISC1 DTNBP1 EXOC1 FSD2 GOLGA2 HOOK2 HSPB1 KAT8 KDM1A KIFC3 KRT15 MAGEA12 MDFI NECAB2 NINL NUP62 NUTM1 PLEKHA5 PNMA1 PSME3 SMAD3 SPAG5 TFIP11 TRAF2 TRAF4 TRIM27 USHBP1 WDR5	131 interacting genes: ABI3 ALKBH4 BACH2 BAHD1 BANP BCKDK BCL6B BEGAIN BEX3 BYSL C19orf54 CALCOCO2 CBL CBLC CCHCR1 CENPE CEP85 CHUK DISC1 DNM2 DPEP2NB DTX3 EXOC7 EYA2 EZHIP FAM214B FAM90A1 FAT1 FBXL18 FRS3 FTH1 GOLGA2 GOLGA6A GOLGA6L9 GORASP1 GORASP2 GPRASP1 HEY2 HGS HMG20A HOMEZ HOXA1 HOXB5 IRAK1 ISYNA1 KANK2 KANSL1 KDM1A KRT31 KRT36 KRT40 LENG8 LNX1 LTBR MAGEC2 MAGED1 MAP3K4 MRPL28 NCF1 NGFR NOS1AP NPAS2 NTRK1 NUDT16L1 PCSK5 PDE4DIP PHLDA1 PICK1 PKD1P1 PLAGL2 PLEKHA7 PLSCR1 POLR2J POLR2J3 PSMC3 QARS1 RAD54L2 RBPMS REXO1L6P RNF114 RNF144B RNF4 RPS6KB1 SF3B4 SIGLEC7 SLC9A3R2 SMURF1 SMURF2 SNRPB SORBS2 SPDL1 SUMO1 TARBP2 TAX1BP1 TBC1D7 TBC1D8 TFAP4 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM27 TRIM37 TSGA10IP TYK2 UBE2D1 UBE2I UBL4A UBL4B UBQLN2 USP7 VPS52 WBP11 WWP1 WWP2 ZBTB16 ZBTB26 ZC3H12C ZMYM5 ZNF177 ZNF275 ZNF3 ZNF512B ZNF559-ZNF177 ZNF581 ZNF620 ZNF688 ZNF784 ZNF835 ZRANB1
Entrez ID		284058	9618
HPRD ID		11254	03915
Ensembl ID		ENSG00000120071	ENSG00000076604
Uniprot IDs		A0A024R9Y2 A0A1W2PRB5 Q7Z3B3	A0A024QZ19 A0A024QZ59 Q9BUZ4
PDB IDs		4CY1 4CY2	2EOD 2YUC 3ZJB 4K8U 4M4E 5YC1
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?