CNR1 and GNAI3

Data Source:
HPRD (in vivo)

		CNR1	GNAI3
Description		cannabinoid receptor 1	G protein subunit alpha i3
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GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton Growth Cone Integral Component Of Mitochondrial Membrane Membrane Raft Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Membrane	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding Drug Binding Identical Protein Binding Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Axonal Fasciculation Aging Response To Nutrient Memory Positive Regulation Of Neuron Projection Development Negative Regulation Of Serotonin Secretion Regulation Of Metabolic Process Sensory Perception Of Pain Positive Regulation Of Fever Generation Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Negative Regulation Of Dopamine Secretion Response To Nicotine Cannabinoid Signaling Pathway Response To Cocaine Glucose Homeostasis Positive Regulation Of Apoptotic Process Response To Morphine Response To Ethanol Negative Regulation Of Action Potential Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Regulation Of Insulin Secretion Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Regulation Of Penile Erection Retrograde Trans-synaptic Signaling By Endocannabinoid Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration	Protein Folding Vesicle Fusion Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Dopamine Receptor Signaling Pathway Brain Development Positive Regulation Of Macroautophagy Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity GTP Metabolic Process Cell Division Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs		Dronabinol Nabilone Ricinoleic Acid SLV319 V24343 AVE-1625 Rimonabant Cannabidiol Propacetamol Otenabant Tetrahydrocannabivarin Medical Cannabis Nabiximols
Diseases
GWAS		Depression in smokers ( 30219690) Gut microbiota (functional units) ( 27694959)	Childhood body mass index ( 33045005) Major depressive disorder ( 20125088)
Interacting Genes		8 interacting genes: GNA15 GNAI1 GNAI2 GNAI3 HCRTR1 MET NSRP1 SSTR5	43 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR
Entrez ID		1268	2773
HPRD ID		00259	00765
Ensembl ID		ENSG00000118432	ENSG00000065135
Uniprot IDs		P21554 S5TLS4 V5KA96	P08754
PDB IDs		1LVQ 1LVR 2B0Y 2KOE 2MZ2 2MZ3 2MZA 5TGZ 5U09 5XR8 5XRA 6KPG 6KQI 6N4B	2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?
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