PCLO and ERC2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		PCLO	ERC2
Description		piccolo presynaptic cytomatrix protein	ELKS/RAB6-interacting/CAST family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Postsynaptic Density Axon Synapse Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse	Cytoskeleton Growth Cone Presynaptic Membrane Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Calcium Ion Binding Profilin Binding Calcium-dependent Phospholipid Binding Structural Constituent Of Presynaptic Active Zone	Protein Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Cytoskeleton Organization Synaptic Vesicle Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Protein Localization To Synapse Maintenance Of Presynaptic Active Zone Structure Synaptic Vesicle Clustering Presynapse To Nucleus Signaling Pathway Presynaptic Active Zone Assembly	Neuromuscular Synaptic Transmission Synaptic Vesicle Priming Regulation Of Synaptic Plasticity Maintenance Of Presynaptic Active Zone Structure
Pathways
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Energy expenditure (24h) ( 28476931) Grapefruit juice consumption ( 31046077) Major depressive disorder ( 21621269 28540843 20351715) Metabolite levels ( 23823483) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)	Acute lymphoblastic leukemia (childhood) ( 22076464) Adult body size ( 32376654) Alcohol dependence ( 24166409) Bipolar disorder and schizophrenia ( 21057379) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549 28869591) Hip bone size ( 31053729) Hip geometry ( 17903296) Intertrochanteric region size ( 31053729) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Morning vs. evening chronotype ( 26955885 27494321) Night sleep phenotypes ( 27126917) Periodontitis (Mean PAL) ( 24024966) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Sense of smell ( 26632684) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990) Trochanter size ( 31053729)
Interacting Genes		4 interacting genes: ERC2 GIT1 GIT2 PCAT1	8 interacting genes: BSN MYB PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1
Entrez ID		27445	26059
HPRD ID		16078	10810
Ensembl ID		ENSG00000186472	ENSG00000187672
Uniprot IDs		Q9Y6V0	O15083
PDB IDs		1UJD
Enriched GO Terms of Interacting Partners?
Tagcloud ?
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Tagcloud (Intersection) ?