PRPF19 and DDX42

Data Source:
BioGRID (two hybrid, two hybrid)

		PRPF19	DDX42
Description		pre-mRNA processing factor 19	DEAD-box helicase 42
Image			No pdb structure
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Lipid Droplet Spindle Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Membrane Nuclear Speck
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity	RNA Binding RNA Helicase Activity Protein Binding ATP Binding
	Biological Process	Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation Transcription-coupled Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Lipid Biosynthetic Process Proteasomal Protein Catabolic Process Cellular Protein Localization Positive Regulation Of Neuron Differentiation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Astrocyte Differentiation Protein K63-linked Ubiquitination Signal Transduction Involved In DNA Damage Checkpoint	MRNA Splicing, Via Spliceosome Protein Localization Regulation Of Apoptotic Process
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS			Body mass index ( 25673413) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		14 interacting genes: DDX42 DNTT EGLN3 ESR1 EXOC7 GSTK1 HSPB1 POLR2A PRPF8 PSMB4 PTEN RPA3 U2AF1 UBE2D3	10 interacting genes: APP DHX15 FBXO25 MDM2 PRPF19 RECQL5 SF3A1 SF3B4 SNRPC U2SURP
Entrez ID		27339	11325
HPRD ID		12214	09909
Ensembl ID		ENSG00000110107	ENSG00000198231
Uniprot IDs		Q9UMS4	Q86XP3
PDB IDs		4LG8 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P
Enriched GO Terms of Interacting Partners?
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