TOX3 and IST1

Data Source:
BioGRID (two hybrid)

		TOX3	IST1
Description		TOX high mobility group box family member 3	IST1 factor associated with ESCRT-III
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Chromatin Extracellular Region Nuclear Envelope Endoplasmic Reticulum-Golgi Intermediate Compartment Centrosome Cytosol Midbody Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Flemming Body
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Chromatin DNA Binding Protein Homodimerization Activity Phosphoprotein Binding	Protein Binding Protein Domain Specific Binding Protein-containing Complex Binding Cadherin Binding MIT Domain Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Protein Localization Abscission Protein Transport Viral Release From Host Cell Multivesicular Body Assembly Neutrophil Degranulation Establishment Of Protein Localization Positive Regulation Of Proteolysis Viral Capsid Secondary Envelopment Positive Regulation Of Collateral Sprouting Cell Division Cytoskeleton-dependent Cytokinesis ESCRT III Complex Disassembly
Pathways			Neutrophil degranulation Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Brain volume in infants (grey matter) ( 28763065) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 21263130 20872241 24143190 25327703 29059683 23535729 23535733 27117709 20585626 31757997 20453838 25956309 19330030) Breast cancer (early onset) ( 24493630) Breast cancer (estrogen-receptor negative) ( 27117709) Breast cancer (male) ( 23001122) Breast cancer in BRCA2 mutation carriers ( 23544012) Chronotype ( 30696823) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Gut microbiota (bacterial taxa) ( 27723756) Hematocrit ( 32888494) Hemoglobin ( 32888494) Major depressive disorder ( 27479909) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Parkinson's disease ( 28892059) Polycystic ovary syndrome ( 22885925 30566500) Restless legs syndrome ( 29029846 21779176)	Apolipoprotein B levels ( 32203549) Blood protein levels ( 28240269) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		12 interacting genes: DUSP21 FHL2 GCM2 IST1 KRTAP9-3 KRTAP9-8 NUP62CL PIN1 POM121 SEZ6L2 TLE5 TSTD2	9 interacting genes: APEH ATXN1 BAG4 CAPN7 CHMP1A SPAST TOX3 UBQLN1 UBQLN2
Entrez ID		27324	9798
HPRD ID		19073	13784
Ensembl ID		ENSG00000103460	ENSG00000182149
Uniprot IDs		O15405	B4DXC9 P53990
PDB IDs			3FRR 3FRS 3JC1 4U7E 4U7I 4U7Y 4WZX 6E8G 6TZ4 6TZ5 6TZA
Enriched GO Terms of Interacting Partners?
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