TNFRSF21 and NSD1

Data Source:
BioGRID (pull down)

		TNFRSF21	NSD1
Description		TNF receptor superfamily member 21	nuclear receptor binding SET domain protein 1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Axon Intrinsic Component Of Plasma Membrane	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding
	Biological Process	B Cell Apoptotic Process Adaptive Immune Response Apoptotic Process Humoral Immune Response Axonal Fasciculation Viral Process Regulation Of Lipid Metabolic Process Negative Regulation Of B Cell Proliferation Negative Regulation Of Myelination Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of T Cell Proliferation Myelination Regulation Of Oligodendrocyte Differentiation T Cell Receptor Signaling Pathway Neuron Apoptotic Process Cellular Response To Tumor Necrosis Factor Oligodendrocyte Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Histone H3-K36 Methylation Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Regulation Of Peptidyl-serine Phosphorylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways		PPARA activates gene expression	PKMTs methylate histone lysines
Drugs
Diseases			Beckwith-Wiedemann syndrome Sotos syndrome and Weaver syndrome
GWAS		Panic disorder ( 19165232) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122)	Activated partial thromboplastin time ( 22703881) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 25282103 31562340) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Narrowest width of the femoral neck ( 30888730) Neutrophil count ( 32888494) Nonsyndromic cleft lip ( 31609978) Urate levels ( 31578528) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		7 interacting genes: CLIP3 MATR3 NSD1 SGTA STX11 TRADD WASH2P	36 interacting genes: AGR2 AR ATRX CCDC125 CYSRT1 ESR1 ESRRA H1-2 H1-3 H1-5 H3-4 H3C1 H4-16 H4C1 HNF4G KRTAP6-2 MDFI NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 NTRK3 POLR2A PPARG RARA RORA RORB RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496
Entrez ID		27242	64324
HPRD ID		05759	09455
Ensembl ID		ENSG00000146072	ENSG00000165671
Uniprot IDs		A0A024RD71 O75509	Q96L73 Q96MN8
PDB IDs		2DBH 3QO4 3U3P 3U3Q 3U3S 3U3T 3U3V	3OOI 6KQP 6KQQ
Enriched GO Terms of Interacting Partners?
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