AGO2 and UBAP2L

Data Source:
BioGRID (proximity labelling technology)

		AGO2	UBAP2L
Description		argonaute RISC catalytic component 2	ubiquitin associated protein 2 like
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Polysome MRNA Cap Binding Complex Membrane RISC Complex Dendrite Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome RISC-loading Complex Ribonucleoprotein Complex	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Cytoplasm Cytoplasmic Stress Granule PcG Protein Complex
	Molecular Function	RNA 7-methylguanosine Cap Binding RNA Polymerase II Complex Binding Core Promoter Sequence-specific DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Translation Initiation Factor Activity Endoribonuclease Activity Protein Binding Protein C-terminus Binding SiRNA Binding MiRNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Endoribonuclease Activity, Cleaving MiRNA-paired MRNA MRNA Cap Binding	RNA Binding Protein Binding
	Biological Process	Translation Translational Initiation Wnt Signaling Pathway, Calcium Modulating Pathway Post-embryonic Development RNA Secondary Structure Unwinding MiRNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Production Of SiRNA Involved In RNA Interference Gene Silencing By RNA Pre-miRNA Processing SiRNA Loading Onto RISC Involved In RNA Interference Post-transcriptional Gene Silencing By RNA Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation MRNA Cleavage Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translational Initiation Positive Regulation Of Translation, NcRNA-mediated Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Gene Silencing By MiRNA RNA Phosphodiester Bond Hydrolysis, Endonucleolytic MRNA Cleavage Involved In Gene Silencing By SiRNA Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Trophoblast Cell Migration Positive Regulation Of MiRNA Mediated Inhibition Of Translation	Binding Of Sperm To Zona Pellucida Stress Granule Assembly Hematopoietic Stem Cell Homeostasis
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neurociticism ( 29500382)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Fish- and plant-related diet ( 32066663) Smoking initiation ( 30617275) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		23 interacting genes: AGO1 BTRC DCP1A DCP2 DDX20 DHX58 DICER1 GEMIN4 KAT5 MAPKAPK2 MIR19A MIRLET7B MIRLET7I NSD2 PFKP PRKRA RAD51 TARBP2 TBK1 TBKBP1 TRIM55 TRIM63 UBC	9 interacting genes: ATXN1 ITCH MTNR1A MTNR1B NEDD4 PLXNA2 PRRC2A SUMO2 ZP3
Entrez ID		27161	9898
HPRD ID		06943	06665
Ensembl ID		ENSG00000123908	ENSG00000143569
Uniprot IDs		Q9UKV8	B4DYY5 F8W726 Q14157
PDB IDs		3LUC 3LUD 3LUG 3LUH 3LUJ 3LUK 3QX8 3QX9 4F3T 4OLA 4OLB 4W5N 4W5O 4W5Q 4W5R 4W5T 4Z4C 4Z4D 4Z4E 4Z4F 4Z4G 4Z4H 4Z4I 5JS1 5JS2 5KI6 5T7B 5WEA 6CBD 6MDZ 6MFN 6MFR 6N4O 6NIT 6RA4
Enriched GO Terms of Interacting Partners?
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