SIGLEC7 and TRAF4

Data Source:
HPRD (in vitro, in vivo)

		SIGLEC7	TRAF4
Description		sialic acid binding Ig like lectin 7	TNF receptor associated factor 4
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Perinuclear Region Of Cytoplasm Plasma Membrane Signaling Receptor Complex
	Molecular Function	Protein Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding WW Domain Binding
	Biological Process	Cell Adhesion Regulation Of Immune Response	Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange By Respiratory System Respiratory Tube Development Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein K63-linked Ubiquitination
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		N-acetyl-alpha-D-glucosamine
Diseases
GWAS		Blood protein levels ( 29875488) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		5 interacting genes: GRB2 LGALS3BP PTPN11 SMIM1 TRAF4	131 interacting genes: ABI3 ALKBH4 BACH2 BAHD1 BANP BCKDK BCL6B BEGAIN BEX3 BYSL C19orf54 CALCOCO2 CBL CBLC CCHCR1 CENPE CEP85 CHUK DISC1 DNM2 DPEP2NB DTX3 EXOC7 EYA2 EZHIP FAM214B FAM90A1 FAT1 FBXL18 FRS3 FTH1 GOLGA2 GOLGA6A GOLGA6L9 GORASP1 GORASP2 GPRASP1 HEY2 HGS HMG20A HOMEZ HOXA1 HOXB5 IRAK1 ISYNA1 KANK2 KANSL1 KDM1A KRT31 KRT36 KRT40 LENG8 LNX1 LTBR MAGEC2 MAGED1 MAP3K4 MRPL28 NCF1 NGFR NOS1AP NPAS2 NTRK1 NUDT16L1 PCSK5 PDE4DIP PHLDA1 PICK1 PKD1P1 PLAGL2 PLEKHA7 PLSCR1 POLR2J POLR2J3 PSMC3 QARS1 RAD54L2 RBPMS REXO1L6P RNF114 RNF144B RNF4 RPS6KB1 SF3B4 SIGLEC7 SLC9A3R2 SMURF1 SMURF2 SNRPB SORBS2 SPDL1 SUMO1 TARBP2 TAX1BP1 TBC1D7 TBC1D8 TFAP4 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM27 TRIM37 TSGA10IP TYK2 UBE2D1 UBE2I UBL4A UBL4B UBQLN2 USP7 VPS52 WBP11 WWP1 WWP2 ZBTB16 ZBTB26 ZC3H12C ZMYM5 ZNF177 ZNF275 ZNF3 ZNF512B ZNF559-ZNF177 ZNF581 ZNF620 ZNF688 ZNF784 ZNF835 ZRANB1
Entrez ID		27036	9618
HPRD ID		05102	03915
Ensembl ID		ENSG00000168995	ENSG00000076604
Uniprot IDs		Q9Y286	A0A024QZ19 A0A024QZ59 Q9BUZ4
PDB IDs		1NKO 1O7S 1O7V 2DF3 2G5R 2HRL	2EOD 2YUC 3ZJB 4K8U 4M4E 5YC1
Enriched GO Terms of Interacting Partners?
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