FGF22 and PTX3

Data Source:
BioGRID (pull down)

		FGF22	PTX3
Description		fibroblast growth factor 22	pentraxin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Fibroblast Growth Factor Receptor Binding Growth Factor Activity	Complement Component C1q Complex Binding (1->3)-beta-D-glucan Binding Protein Binding Identical Protein Binding Virion Binding
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Protein Kinase B Signaling	Ovarian Cumulus Expansion Response To Yeast Inflammatory Response Opsonization Extracellular Matrix Organization Neutrophil Degranulation Negative Regulation By Host Of Viral Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Phagocytosis Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process
Pathways		PI3K Cascade PIP3 activates AKT signaling FGFR1b ligand binding and activation FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Neutrophil degranulation
Drugs
Diseases
GWAS			Body mass index ( 26426971)
Interacting Genes		1 interacting genes: PTX3	15 interacting genes: C1QA C1QB C1QC CFH FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF5 FGF7 FGF8 MTNR1A
Entrez ID		27006	5806
HPRD ID		05784	03928
Ensembl ID		ENSG00000070388	ENSG00000163661
Uniprot IDs		K7ELB9 Q9HCT0	P26022
PDB IDs
Enriched GO Terms of Interacting Partners?
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