HBP1 and UBE2H

Data Source:
BioGRID (enzymatic study)

		HBP1	UBE2H
Description		HMG-box transcription factor 1	ubiquitin conjugating enzyme E2 H
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Speck	Nucleus Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Binding Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Cycle Arrest Wnt Signaling Pathway	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)
Interacting Genes		19 interacting genes: ANKRD2 CASP8 CD2AP CREBBP EP300 ESR1 EWSR1 HDAC1 KIFBP RB1 RB1CC1 RBL2 SAP30 SIN3A SMAD1 TCF4 TMEM37 UBE2H ZNF212	68 interacting genes: BRAP BYSL CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GOLGA2 H2AC18 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MKRN3 NEURL1 NHLRC1 POLL POLM PRKN PSME3 RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TLE5 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBA1 UBASH3B UBOX5 UBR2 UBR3
Entrez ID		26959	7328
HPRD ID		13634	03052
Ensembl ID		ENSG00000105856	ENSG00000186591
Uniprot IDs		A0A024R722 B4DJ36 O60381	A0A3B3IU20 A4D1L5 P62256
PDB IDs		2E6O 3QVE	2Z5D
Enriched GO Terms of Interacting Partners?
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