GGCX and ATP2C1

Data Source:
HPRD (in vivo)

		GGCX	ATP2C1
Description		gamma-glutamyl carboxylase	ATPase secretory pathway Ca2+ transporting 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Gamma-glutamyl Carboxylase Activity Vitamin Binding	Calcium Transmembrane Transporter Activity, Phosphorylative Mechanism ATP Binding Proton-exporting ATPase Activity, Phosphorylative Mechanism Manganese Transmembrane Transporter Activity, Phosphorylative Mechanism ATPase Activity Metal Ion Binding
	Biological Process	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation	Calcium Ion Transport Manganese Ion Transport Cellular Calcium Ion Homeostasis Epidermis Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Actin Cytoskeleton Reorganization Golgi Calcium Ion Homeostasis Golgi Calcium Ion Transport Ion Transmembrane Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Proton Transmembrane Transport
Pathways		Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9	Ion transport by P-type ATPases
Drugs		Coagulation factor VIIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human	Enflurane Isoflurane Methoxyflurane Desflurane Sevoflurane Calcium
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)	Hailey-Hailey disease; Benign familial pemphigus
GWAS		Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)	Refractive error ( 32231278) Restless legs syndrome ( 29029846) Waist circumference ( 28552196)
Interacting Genes		7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2	3 interacting genes: F2RL1 GPR35 GTF2IRD1
Entrez ID		2677	27032
HPRD ID		00665	05089
Ensembl ID		ENSG00000115486	ENSG00000017260
Uniprot IDs		P38435	B4E295 B4E2Q0 P98194
PDB IDs
Enriched GO Terms of Interacting Partners?
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