GFRA2 and PPP3CC

Data Source:
BioGRID (affinity chromatography technology)

		GFRA2	PPP3CC
Description		GDNF family receptor alpha 2	protein phosphatase 3 catalytic subunit gamma
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Receptor Complex	Cytoplasm Mitochondrion Cytosol Calcineurin Complex Presynapse Glutamatergic Synapse
	Molecular Function	Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity	Protein Binding Calmodulin Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Negative Regulation Of Protein Autophosphorylation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway	Protein Dephosphorylation Brain Development Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling	Activation of BAD and translocation to mitochondria DARPP-32 events
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Diisocyanate-induced asthma ( 25918132) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Migraine with aura ( 23793025) Neuropathic pain in type 2 diabetes ( 24974787) Nicotine dependence symptom count ( 25555482) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to lithium treatment in bipolar disorder ( 26806518) Trunk fat mass ( 28552196) Verbal declarative memory ( 25648963)	General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 20205591) Verbal declarative memory ( 25648963)
Interacting Genes		2 interacting genes: GDNF NRTN	14 interacting genes: AMPH APP BCL2 BMPR1B CABIN1 CSNK2B HAX1 ITPKC PPP3R1 SDC2 SPATA33 TGFBR1 THAP7 UNC119
Entrez ID		2675	5533
HPRD ID		11801	00236
Ensembl ID		ENSG00000168546	ENSG00000120910
Uniprot IDs		O00451	P48454
PDB IDs		5MR4 5MR5 6GL7 6Q2O 6Q2R
Enriched GO Terms of Interacting Partners?
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