GDNF and GFRA1

Data Source:
HPRD (in vivo, in vitro)

		GDNF	GFRA1
Description		glial cell derived neurotrophic factor	GDNF family receptor alpha 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus	Multivesicular Body Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Growth Factor Activity Glial Cell-derived Neurotrophic Factor Receptor Binding Receptor Tyrosine Kinase Binding Protein Homodimerization Activity Chemoattractant Activity Involved In Axon Guidance	Signaling Receptor Binding Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity
	Biological Process	MAPK Cascade Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Neural Crest Cell Migration Organ Induction Postsynaptic Membrane Organization Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Nervous System Development Axon Guidance Peripheral Nervous System Development Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Regulation Of Gene Expression Dorsal Spinal Cord Development Postganglionic Parasympathetic Fiber Development Peristalsis Neuron Projection Development Positive Regulation Of Monooxygenase Activity Positive Regulation Of Dopamine Secretion Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Enteric Nervous System Development Sympathetic Nervous System Development Embryonic Organ Development Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ureteric Bud Formation Regulation Of Morphogenesis Of A Branching Structure Chemoattraction Of Axon Commissural Neuron Axon Guidance Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Semaphorin-plexin Signaling Pathway	MAPK Cascade Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling	NCAM1 interactions RAF/MAP kinase cascade RET signaling
Drugs		Chondroitin sulfate
Diseases		Hirschsprung disease (HD) Congenital central hypoventilation syndrome (CCHS)
GWAS		Asthma ( 29273806) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Major depressive disorder ( 20125088)	Blood protein levels ( 30072576 29875488) Delirium ( 29631748) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Malaria ( 31844061) Migraine without aura ( 28952330) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603)
Interacting Genes		8 interacting genes: AGTRAP GFRA1 GFRA2 MUC1 NCAM1 RET SCAMP5 SYP	5 interacting genes: GDNF NCAM1 NRTN RET SOCS3
Entrez ID		2668	2674
HPRD ID		02906	03291
Ensembl ID		ENSG00000168621	ENSG00000151892
Uniprot IDs		A0A0S2Z3T2 A0A0S2Z3V2 P39905	B7Z856 P56159
PDB IDs		2V5E 3FUB 4UX8 6Q2N	6Q2N
Enriched GO Terms of Interacting Partners?
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